Kenneth A. Johnson, Ph.D Publications

 

  1. Huddleston, J. P., Schroeder, G. K., Johnson, K. A. and Whitman, C. P. (2012) A Pre-Steady-State Kinetic Analysis of the αY60W mutant of trans-3-Chloroacrylic Acid Dehalogenase: Implications for the Mechanism of the Wild Type Enzyme. Biochemistry 51, 9420-9435. [Link]
  2. Heidebrecht, T.; Fish, A.; von Castelmur, E.; Johnson, K.; Zaccai, G.; Borst, P.; Perrakis, A. (2012) Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC; evidence for a rapid conformational change upon DNA binding. J. Am. Chem. Soc 134, 13357-65. [Link]
  3. Johnson, K.A. (2012) DNA replication caught in the act. Nature 487: 177-8. [Link]
  4. Kirmizialtin, S., Nguyen, V., Johnson, K. A., and Elber, R. (2012) How Conformational Dynamics of DNA Polymerase Select Correct Substrates: Experiments and Simulations. Structure 20(4): 618-27 [Link]
  5. Jin Z, Leveque V, Ma H, Johnson KA, Klumpp K (2012) Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex. J Biol Chem. 287(13):10674-83. [Link]
  6. Schroeder, G. K., Johnson, W. H., Huddleston, J. P., Serrano, H., Johnson, K. A. and Whitman, C. P. (2012) Reaction of cis-3-Chloroacrylic Acid Dehalogenase with an Allene Substrate, 2,3-Butadienoate: Hydration Via an Enamine. J. Am. Chem. Soc., 134, 293-304 [Link}
  7. Jin Z, Deval J, Johnson KA, Swinney DC.(2011) Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity. J Biol Chem. 2011 Jan 21;286(3):2067-77. Epub 2010 Nov 15. [Link]
  8. Holman, G. G., Zewail-Foote, M., Johnson, K. A., Iverson, B. L. A (2011) Sequence-Specific Threading Tetra-intercalator with an Extremely Slow Dissociation Rate Constant. Nature Chemistry 3, 875-81. [Link]
  9. Estep, P. A., and Johnson, K. A. (2011) Effect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity. Biochemistry 50, 6376-86 [Link]
  10. Kellinger, M. W., and Johnson, K. A. (2011) Role of induced-fit in limiting discrimination against AZT by HIV reverse transcriptase. Biochemistry 50, 5008-5015. [Link]
  11. Karnas, E., Kim, Sung Kuk, Johnson, K. A., Sessler, J.; Ohkubo, K., Fukuzumi, S. (2011) Stopped-Flow Kinetic Analysis of the Interaction of Cyclo[8]pyrrole with Anions. JACS 132, 16617-22 [Link]
  12. Jin, Z., Johnson, K. A. (2011) Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase. J. Biol. Chem. 286,1312-22 [Link]
  13. Batabyal, D., McKenzie, J. L., and Johnson, K. A. (2010) Role of histidine-932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease. J. Biol. Chem. 285, 34191-201 [Link]
  14. Lee, YS, Lee, SJ, Demeler, B, Molineux, IJ, Johnson, KA and Yin, Y.W. (2010) Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity. J Biol Chem. 285: 1490-1499. [Link]
  15. Kellinger, M. W. and Johnson, K. A. (2010) Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase. Proc. Natl. Acad. Sci. U. S. A. 107(17), 7734-7739. [Link]
  16. Johnson, K. A. (2009) Fitting enzyme kinetic data with KinTek Global Kinetic Explorer. Methods Enzymol. 467, 601-26. [Link]
  17. Robertson, B. A., Schroeder, G. K., Jin, Z., Johnson, K. A., and Whitman, C. P. (2009) Pre-steady state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications. Biochemistry 48, 11737-11744. [Link]
  18. Brandis, J. W. and Johnson, K.A. (2009) High-cell density shake-flask expression and rapid purification of the large fragment of Thermus aquaticus DNA polymerase I using a new chemically and temperature inducible expression plasmid in Escherichia coli. Protein Expression and Purification 63, 120-127. [Link]
  19. Tsai, Y.-C., Jin, Z., and Johnson, K. A. (2009). Site-specific labeling of T7 DNA polymerase with a conformationally-sensitive fluorophore and its use in detecting single nucleotide polymorphisms, Analytical Biochemistry 384, 136-144. [Link]
  20. Johnson K.A., Simpson, Z. B, and Blom, T. (2009) FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data., Anal. Biochem. 387, 30-41 [Link]
  21. Johnson K.A., Simpson, Z. B, and Blom, T. (2009) Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data., Anal. Biochem. 387, 20-29 [Link]
  22. Fowler, J. D., Brown J. A., Johnson, K. A. and Suo, Z. (2008) Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase. J. Biol. Chem. 283, 15339-48 [Abstract] [Full Text]
  23. Lee, H. R. Helquist, S. A., Kool, E. T., and Johnson, K. A. (2008) Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. J. Biol. Chem. 283, 14411-6. [Abstract] [Full Text]
  24. Lee, H. R. Helquist, S. A., Kool, E. T., and Johnson, K. A. (2008) Importance of Hydrogen Bonding to Efficiency and Specificity of the Human Mitochondrial DNA Polymerase, J. Biol. Chem. 283, 14402-10. [Abstract] [Full Text]
  25. Johnson, K. A. (2008) Role of induced-fit in enzyme specificity: a molecular forward/reverse switch. J. Biol. Chem., 283, 26297-26301 [Abstract] [Full Text]
  26. Lee, H. R. and Johnson, K. A. (2007) Fidelity and processivity of reverse transcription by the human mitochondrial DNA polymerase. J. Biol. Chem. 282, 31982-9 [Abstract] [Full Text]
  27. Hanes, J. W. and Johnson, K. A. (2007) Real-time Measurement of Pyrophosphate Release Kinetics. Anal. Biochem., 372, 125-7 [Link]
  28. Hanes, J. W. and Johnson, K. A. (2007) A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase. Nucleic Acids Research, 35, 6973-83 [Abstract] [Full Text]
  29. Hanes, J. W., Zhu, Y., Parris, D. S., and Johnson, K. A. (2007) Enzymatic Therapeutic Index of Acyclovir: Viral versus Human Polymerase γ Specificity. J. Biol. Chem. 282, 25159-25167 [Abstract] [Full Text]
  30. Hanes, J. W. and Johnson, K. A. (2007) Exonuclease Removal of Dideoxycytidine (Zalcitabine) by the Human Mitochondrial DNA Polymerase. Antimicrob Agents Chemother., 52, 253-8. [Link]
  31. Hanes, J. W., Thal, D. M. and Johnson, K. A. Incorporation and Replication of 8-oxo-deoxyguanosine by the Human Mitochondrial DNA Polymerase. J. Biol. Chem, 281, 36241-36248. [Abstract] [Full Text]
  32. Lee, H. R. and Johnson, K. A. (2006) Fidelity of the Human Mitochondrial DNA Polymerase. J. Biol. Chem, 281, 36236-36240 [Abstract] [Full Text]
  33. Tsai, Y-C. and Johnson, K. A. (2006) A New Paradigm for DNA Polymerase Specificity. Biochemistry 45, 9675-9687 [Abstract] [Full Text]
  34. Auerbach, S. D. and Johnson, K. A. (2005) Kinetic Effects of Kinesin Switch-I and Switch-II Mutations. J. Biol. Chem. 280, 37061-37068 [Abstract] [Full Text]
  35. Auerbach, S. D. and Johnson, K. A. (2005) Alternating-site ATPase Pathway of Rat Conventional Kinesin. J. Biol. Chem. 280, 37048-37060 [Abstract] [Full Text]
  36. Hanes, J., and Johnson, K. A. (2005) Analysis of Single Nucleotide Incorporation Reactions by Capillary Electrophoresis. Anal. Biochem. 340, 35-40. [Link]
  37. Johnson, K. A. (2004)  "DNA Polymerases:  Kinetics and Mechanism" in Encyclopedia of Biological Chemistry (W.J. Lennarz & M.C. Lane, eds) Elsevier, Oxford, Vol. 1, pp 734-739.
  38. Wang, L. Z., Kenyon, G. L., and Johnson, K. A. (2004) Novel Mechanism of Inhibition of HIV-1 Reverse Transcriptase by KM-1.  J. Biol. Chem. 279, 38424-38432 [Link]
  39. Feng, J.Y., Murakami, E., Zorca, S.M., Johnson, A.A., Johnson, K. A., Schinazi, R.F., Furman, P.A. and Anderson, K.S. (2004)  Relationship between Antiviral Activity and Host Toxicity:  Comparing the Incorporation of FTC-triphosphate Analogs by HIV-1 RT and Human Mitochondrial DNA Polymerase.  Antimicrob Agents Chemother. 48(4):1300-6. [Link]
  40. Lee, H., Hanes, J., and Johnson, K. A. (2003)  Toxicity of Nucleoside Analogs Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase.  Biochemistry, 42:14711-9. [Link]
  41. Murakami, E., Feng J.Y., Lee, H, Hanes, J., Johnson, K.A., Anderson, K.S.  (2003) Characterization of a novel reverse transcriptase and other RNA associated catalytic activities by human DNA polymerase gamma: Importance in mitochondrial DNA replication. J. Biol. Chem., 278, 36403-9 [Link]
  42. Johnson, K. A. (2003)  "Enzyme Kinetics:  Transient Phase" in Nature Encyclopedia of Life Sciences. McMillan Press.  [Link]
  43. Fraley, A.W., Chen, D., Johnson, K.A., McLaughlin, L.W. (2003) An HIV Reverse Transcriptase-Selective Nucleoside Chain Terminator.  J. Am. Chem. Soc. 125, 616-617. [Link]
  44. Johnson, A.A., Ray, A. S., Hanes, J., Suo, Z., Colacino, J. M., Anderson, K. S., and Johnson, K. A. (2001) Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase.  J. Biol. Chem. 276, 40847-40857 [Link]
  45. Johnson, A.A., and Johnson, K. A. (2001) Exonuclease proofreading by human mitochondrial DNA polymerase.  J. Biol. Chem., 2001 276, 38097-38107 [Link]
  46. Johnson, A.A., and Johnson, K. A. (2001) Fidelity of Nucleotide Incorporation by Human Mitochondrial DNA Polymerase.  J. Biol. Chem., 2001 276, 38090-38096 [Link]
  47. Joy Y. Feng, Allison A. Johnson, Kenneth A. Johnson, Karen S. Anderson (2001) Insights into the Molecular Mechanism of Mitochondrial Toxicity by AIDS Drugs.  J. Biol. Chem, 2001 276: 23832-23837 [Link]
  48. Johnson, A.A., Tsai, Y-C., Graves, S.W. and Johnson, K.A. (2000) Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization.  Biochemistry 39, 1702-1708. [Link]
  49. Lewis, J., Johnson, K.A., and Anderson, K.S. (1999) The catalytic mechanism of EPSP Synthase revisited.  Biochemistry 38, 7372-7379 [Link]
  50. Mandelkow, E., Johnson, K.A. (1998). The Structural and Mechanochemical Cycle of Kinesin. TIBS 23, 429-434 [Link]
  51. Suo, Z., Lippard, S.J. and Johnson, K. A. (1998) Single d(GpG)/cis-Diammineplatinum(II) Adduct-Induced Inhibition of DNA Polymerization.  Biochemistry 38, 715-726 [Link]
  52. Suo, Z., and Johnson, K. A. (1998) DNA Secondary Structure Effects on DNA Synthesis Catalyzed by HIV-1 Reverse Transcriptase.  J. Biol. Chem.273, 27259-27267 [Link]
  53. Suo, Z., and Johnson, K. A. (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.  J. Biol. Chem.273, 27250-27258 [Link]
  54. Graves, S. W., Johnson, A. A., and Johnson, K. A. (1998)  Expression, Purification and Initial Kinetic Characterization of the Large Subunit of Human DNA Polymerase Gamma.  Biochemistry, 37, 6050-6058. [Link]
  55. Johnson, K. A. (1998)  Advances in Transient-State Kinetics.  Current Opinion in Biotechnology 9, 87-89. [Link]
  56. Moyer, M. L. and Johnson, K. A. (1998)  Pathway of ATP hydrolysis by Monomeric and Dimeric Kinesin.    Biochemistry 37, 800-813. [Link]
  57. Gilbert, S. P., Moyer, M. L. and Johnson, K. A.  (1998) Alternating Site Mechanism of the Kinesin ATPase.  Biochemistry 37, 792-799. [Link]
  58. Wu, Shu Ling, Johnson, K. A., Horrocks, W. DeW. (1997).  Kinetics of Formation of Ca(2+) Complexes of Acyclic and Macrocyclic Poly(amino carboxylate) Ligands: Bimolecular Rate Constants for the Fully-Deprotonated Ligands Reveal the Effect of Macrocyclic Ligand Constraints on the Rate-Determining Conversions of Rapidly-Formed Intermediates to the Final Complexes.  Inorg. Chem.  36, 1884-1889. [Link]
  59. Suo, Z., and Johnson, K. A. (1997) RNA Secondary Structure Switching during DNA Synthesis Catalyzed by HIV-1 Reverse Transcriptase.  Biochemistry 36, 14778-14785 [Link]
  60. Hacker, K., and Johnson, K. A. (1997)  A Hexameric Helicase Encircles one DNA Strand and Excludes the other during DNA Unwinding.  Biochemistry 36, 14080-14087 [Link]
  61. Suo, Z., and Johnson, K. A. (1997)  Effect of RNA Secondary Structure on RNA Cleavage Catalyzed by HIV-1 Reverse Transcriptase.  Biochemistry 36, 12468-12476 [Link]
  62. Suo, Z., and Johnson, K. A. (1997)  Effect of RNA Secondary Structure on the Kinetics of DNA Synthesis Catalyzed by HIV-1 Reverse Transcriptase.  Biochemistry 36, 12459-12467 [Link]
  63. Spence, R. A., and Johnson, K. A.  (1996)  Therapeutic Potential of Nonnucleoside Reverse Transcriptase Inhibitors in the Treatment of HIV Infection.  Exp. Opin. Invest. Drugs 5, 985-1001. [Link]
  64. Moyer, M. L., Gilbert, S. P. and Johnson, K. A. (1996)  Purification and Characterization of Two Monomeric Kinesin Constructs.  Biochemistry 35, 6321-6329. [Link]
  65. Brandis, J. W., Edwards, S. G. and Johnson, K. A. (1996)  Slow Rate of Phosphodiester Bond Formation Accounts for the Strong Bias that Taq DNA Polymerase Shows Against 2’,3’-dideoxynucleotide Terminators.  Biochemistry 35, 2189-2200. [Link]
  66. Spence, R. A., Anderson, K. S. and Johnson, K. A.  (1996)  HIV-1 Resistance to Nonnucleoside Inhibitors.  Biochemistry 35, 1054-1063 [Link]
  67. Johnson, K. A. and Gilbert, S. P. (1995)  Pathway of the Microtubule-Kinesin ATPase.  Biophys. J. 68, s173-s179. [Link]
  68. Spence, R. A., Kati, W. M., Anderson, K. S. and Johnson, K. A. (1995)  Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors.  Science 267, 988-993. [Link]
  69. Gilbert, S. P., Webb, M. R., Brune, M. and Johnson, K. A.  (1995)  Pathway of Processive ATP Hydrolysis by Kinesin.  Nature 373, 671-676. [Link]
  70. Johnson, K. A. (1995)   Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates.  Methods in Enzymology 249, 38-61. [Link]
  71. Johnson, K. A. (1995)  Transient State Kinetic Analysis of Enzyme Reactions in Molecular Biology and Biotechnology:  A comprehensive Desk Reference.  Edited by Robert A. Meyers.  (VCH Pub., Inc.) pp. 292-294. [Link to Book]
  72. Correia, J. J., Gilbert, S. P., Moyer, M. L. and Johnson, K. A. (1995)  Sedimentation Studies on the Kinesin Motor Domain Constructs K401, K366, K341.  Biochemistry 34, 4898-4907. [Link]
  73. Donlin, M. J., and Johnson, K. A. (1995)  Mutants Affecting Nucleotide Recognition by T7 DNA Polymerase.  Biochemistry 33, 14908-14917. [Link]
  74. Gilbert, S. P. and Johnson, K. A. (1994)  Pre-steady-state Kinetics of the microtubule-kinesin ATPase.  Biochemistry 33, 1951-1960. [Link]
  75. Kunkel, T. A., Patel, S. A. and Johnson, K. A. (1994)  Error-Prone Replication of Repeated DNA Sequences by T7 DNA Polymerase in the Absence of its Processivity Subunit.  Proc. Natl. Acad. Sci USA 91, 6830-6834. [Link]
  76. Bevilacqua, P. C., Johnson, K. A., and Turner, D. H. (1993)  Cooperative and anticooperative binding to a ribozyme.  Proc. Natl. Acad. Sci. USA  90, 8357-8361. [Link]
  77. Kuan, I, Johnson, K. A. and Tien, M. (1993)  Kinetic Analysis of Manganese Peroxidases:  The reaction with Manganese Complexes.  J. Biol. Chem. 268, 20064-20070. [Link]
  78. Gilbert, S. P. and Johnson, K. A. (1993) Expression, Purification, and Characterization of the Drosophila Kinesin Motor Domain Produced in E. coliBiochemistry 32, 4677-4684. [Link]
  79. Harrison, B. C., Marchese-Ragona, S. P., Cheng, N., Steven, A. C. and Johnson, K. A. (1993).  Decoration of the microtubule surface by one kinesin head per tubulin heterodimer.  Nature 362, 73-75. [Link]
  80. Johnson, K. A. (1993) Conformational Coupling in DNA Polymerization.  Ann. Rev. Biochem. 62, 685-713. [Link]
  81. Bevilacqua, P. C., Kierzek, R., Johnson, K. A. and Turner, D. H. (1992).  Dynamics of Ribozyme Binding of Substrate Revealed by Fluorescence Detected Stopped-Flow.  Science 258, 1355-1358. [Link]
  82. Kati, W. M., Johnson, K. A., Jerva, L. F. and Anderson, K. S. (1992) Mechanism and Fidelity of HIV Reverse Transcriptase.  J. Biol. Chem. 267, 25988-25997. [Link]
  83. Johnson, K. A. (1992) Transient State Kinetic Analysis of Enzyme Reaction Pathways.  The Enzymes, XX, 1-61. [Link]
  84. Johnson, K. A. (1992) Conformational Coupling in DNA Polymerase Information Transfer.  Trans. Royal Soc. London 336, 107-126 [Link]
  85. Patel, S, Rosenberg, A. H., Studier, F. W. and Johnson, K. A. (1992)  Large Scale Purification and Biochemical Characterization of T7 Primase/Helicase Proteins: Evidence for Homodimer and Heterodimer Formation.  J. Biol. Chem. 267, 15013-15021. [Link]
  86. Rosenberg, A. H., Patel, S, Johnson, K. A. and Studier, F. W. (1992)  Cloning and Expression of Gene 4 of Bacteriophage T7, and Creation and Analysis of T7 Mutants Lacking the 4A Primase/Helicase of the 4B Helicase.  J. Biol. Chem. 267, 15002-15012. [Link]
  87. Anderson, K. S., Miles, E. W. and Johnson, K. A. (1991)  Serine Modulates Substrate Channeling in Tryptophan Synthase: A Novel Intersubunit Triggering Mechanism. J. Biol. Chem. 266, 8020-8033. [Link]
  88. Anderson, K. S., Kati, W. M., Ye, C. Z., Liu, J., Walsh, C. T., Benesi, A. J. and Johnson, K. A. (1991)  Isolation and Structure Elucidation of the 4-amino-4-deoxychorismate Intermediate in the PABA Synthase Pathway.  J. Am. Chem. Soc. 113, 3198-3200. [Link]
  89. Donlin, M. J., Patel, S. S. and Johnson, K. A. (1991)  Kinetic Partitioning Between the Exonuclease and Polymerase Sites in DNA Error Correction.  Biochemistry 30, 538-546. [Link]
  90. Wong, I., Patel, S. S. and Johnson, K. A. (1991)  An Induced-Fit Kinetic Mechanism for DNA Replication Fidelity: Direct Measurement by Single Turnover Kinetics.  Biochemistry 30, 526-537. [Link]
  91. Patel, S. S., Wong, I. and Johnson, K. A. (1991)  Pre-steady-state Kinetic Analysis of Processive DNA Replication Including Complete Characterization of an Exonuclease Deficient Mutant.  Biochemistry 30, 511-525. [Link]
  92. Marchese-Ragona, S. P., Facemyer, K. C. and Johnson, K. A. (1991)  Structural Studies of the Dynein ATPases.  Comparative Spermatology 20 Years After. pp 403-406. [Link to Book]
  93. Anderson, K. S., and Johnson, K. A. (1990)  Kinetic and Structural Analysis of Enzyme Intermediates:  Lessons from EPSP Synthase.  Chem. Rev. 90, 1131-1149. [Link]
  94. Shimizu, T., Okuno, M., Marchese-Ragona, S. P. and Johnson, K. A. (1990)  Phosphorothioate Analogs of ATP as the Substrates of Dynein and Ciliary or Flagellar Movement.  Eur. J. Biochem. 191, 543-550. [Link]
  95. Chilcote, T. J., and Johnson, K. A. (1990) Phosphorylation of Tetrahymena 22 S Dynein.  J. Biol. Chem. 265, 17257-17266. [Link]
  96. Sikorski, J. A., Anderson, K. S., Cleary, D. G., Miller, M. J., Pansegrau, P. D., Ream, J. E., Sammons, R. D. and Johnson, K. A.  (1990)  An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase:  Chemical Mechanism and  Glyphosate Inhibition Studies. Chemical Aspects of Enzyme Biotechnology, ed. T. O. Baldwin, Plenum Press. (New York) pp. 23-39. [Link to Book]
  97. Johnson, K. A. and Benkovic, S. J. (1990) Analysis of Protein Function by Mutagenesis.  The Enzymes XIX, 159-211. [Link]
  98. Anderson, K. S. and Johnson, K. A. (1990) Kinetic Competence of the EPSP Synthase Tetrahedral Intermediate.  J. Biol. Chem. 265, 5567-5572. [Link]
  99. Anderson, K. S., Sammons, R. D., Leo, G. C., Sikorski, J. A., Benesi, A. J. and Johnson, K. A.  (1990) Observation by 13C-NMR of the EPSP Synthase Tetrahedral Intermediate Bound to the Enzyme Active Site.  Biochemistry 29, 1460-1465. [Link]
  100. Detrich, H. W., Johnson, K. A. and Marchese-Ragona, S. P. (1989)  Polymerization of Antarctic Fish Tubulins at Low Temperatures: Energetic Aspects.  Biochemistry 28, 10085-10093. [Link]
  101. Porter, M. E., and Johnson, K. A. (1989) Dynein Structure and Function.  Annu. Rev. Cell Biol. 5, 119-152. [Link]
  102. Marchese-Ragona, S. P., Facemyer, K. C. and Johnson, K. A. (1989)  Structure of the α, β, and γ-Heavy Chains of 22 S Outer Arm Dynein Obtained from Tetrahymena cilia.  J. Biol. Chem. 264, 21361-21368. [Link]
  103. Adams, J., Matthews, C. R., Johnson, K. A. and Benkovic, S. J. (1989) Effects of Distal Point Site Mutations on the Binding and Catalysis of Dihydrofolate Reductase from E. coli.   Biochemistry 28, 6611-6618. [Link]
  104. Shimizu, T., Tatsuo, K., Domanico, P. L., Marchese-Ragona, S. P. and Johnson, K. A. (1989)  Adenosine 5-O-(3-thiophosphate) Hydrolysis by Dynein.  Biochemistry 28, 7022-7027. [Link]
  105. Shimizu, T., Marchese-Ragona, S. P. and Johnson, K. A. (1989) Activation of the Dynein ATPase by Crosslinking to Microtubules.  Biochemistry 28, 7016-7021. [Link]
  106. Holzbaur, E. L. F. and Johnson, K. A. (1989) Microtubules Accelerate ADP Release by Dynein.  Biochemistry 28, 7010-7016. [Link]
  107. Sulewski, M., Marchese-Ragona, S. P., Johnson, K. A. and Benkovic, S. J. (1989) Mechanism of Polynucleotide Phosphorylase.  Biochemistry 28, 5855-5864. [Link]
  108. Holzbaur, E. L. F. and Johnson, K. A. (1989) ADP Release is Rate Limiting in Steady State Turnover by the Dynein ATPase.  Biochemistry 28,5577-5585. [Link]
  109. Pember, S. O., Johnson, K. A., Villafranca, J. J. and Benkovic,  S. J. (1988)  Mechanistic Studies of Phenylalanine Hydroxylase from Chromobacterium violaceum. Evidence for the Formation of an Enzyme-Oxygen Complex.  Biochemistry 28, 2124-2130. [Link]
  110. Hastie, A. T., Marchese-Ragona, S. P., Johnson, K. A. and Wall, J. S.  (1988) Structure and Mass of Mammalian Respiratory Ciliary Outer Arm 19S Dynein.  Cell Motil. Cytoskel. 11, 157-166. [Link]
  111. Marchese-Ragona, S. P. and Johnson, K. A. (1988)  STEM Analysis of the Dynein ATPase.  Electron Microsc Rev. 1, 141-153. [Link]
  112. Anderson, K. S., Benesi, A. J., Sikorski, J. A. and Johnson, K. A. (1988)  Isolation and Structural Elucidation of the Tetrahedral Intermediate in the EPSP Synthase Reaction Pathway  J. Am. Chem. Soc. 110, 6577-6579. [Link]
  113. Anderson, K. S., Sikorski, J. A. and Johnson, K. A.  (1988)  A Tetrahedral Intermediate in the EPSP Synthase Reaction Observed by Rapid Quench Kinetics.  Biochemistry 27, 7395-7406. [Link]
  114. Brokaw, C. J. and Johnson, K. A. (1989) The Generation of Flagellar Waveform from Dynein-Induced Microtubule Sliding, in Cell Movement, edited by F. D. Warner, P. Satir and I. R. Gibbons (1989) Alan R. Liss, New York, pp 191-199.
  115. Chilcote, T. J. and Johnson, K. A. (1989) The Microtubule-Dynein Crossbridge Cycle and the Kinetics of AMPPNP Binding, in Cell Movement, edited by F. D. Warner, P. Satir and I. R. Gibbons (1989) Alan R. Liss, New York, pp 235-245.
  116. Anderson, K. S., Sikorski, J. A. and Johnson, K. A.  (1988)  Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements.  Biochemistry 27, 1604-1610. [Link] -->
  117. Fierke, C. A., Kuchta, R. D., Johnson, K. A. and Benkovic, S. J.  (1987)  Implications for Enzymic Catalysis from Free-energy Reaction Coordinate Profiles.  Cold Spring Harbor Symp. Quant. Biol. 52, 631-638. [Link]
  118. Andrawis, A., Johnson, K. A. and Tien, M. (1987)  Studies on Compound I Formation of the Lignin Peroxidase from Phanerochaete chrysosporium.  J. Biol. Chem. 263, 1195-1198.
  119. Marchese-Ragona, S. P., Gagnon, C., White, D., Belles-Isles, M. and Johnson, K. A. (1987)  Structure and Mass Analysis of 12S and 19S Dynein Obtained from Bull Sperm Flagella.  J. Cell Motil. Cytoskel. 8, 368-374. [Link]
  120. Marchese-Ragona, S. P., Wall, J. S. and Johnson, K. A. (1987)  Structure and Mass Analysis of 14S Dynein from Tetrahymena Cilia.  J. Cell Biol. 106, 127-132.
  121. Kuchta, R. D., Mizrahi, V., Benkovic, P. A., Johnson, K. A. and Benkovic, S. J.  (1987)  The Kinetic Mechanism of DNA Polymerase I.  Biochemistry 26, 8410-8417.
  122. Taira, K., Fierke, C. A., Chen, J.-T., Johnson, K. A. and Benkovic, S. J. (1987) On Interpreting the Inhibition of and Catalysis by Dihydrofolate Reductase.  TIBS 12, 275-279.
  123. Fierke, C. A., Johnson, K. A. and Benkovic, S. J.  (1986) Construction and Evaluation of the Kinetic Scheme Associated with Dihydrofolate Reductase from E. coliBiochemistry 26, 4085-4092. [Link]
  124. Johnson, K. A.  (1986)  Rapid Kinetic Analysis of Mechanochemical ATPases.  Meth. Enzymol. 134, 677-705. [Link]
  125. Johnson, K. A.  (1986)  Preparation and Properties of Dynein from Tetrahymena cilia.  Meth. Enzymol. 134, 306-317. [Link]
  126. Johnson, K. A., Marchese-Ragona, S. P., Clutter, D. B., Holzbaur, E. L. F. and Chilcote, T. J.  (1986)  Dynein Structure and Function.  J. Cell Sci. Suppl. 5, 189-196. [Link]
  127. Breen, P. J., Horrocks, W. DeW. and Johnson, K. A.  (1986)  A Stopped-flow Study of Ligand Exchange Kinetics Between Terbium(III) and Ca(II)-EDTA.  Inorg. Chem. 25, 1968–1971. [Link]
  128. Holzbaur, E. L. F. and Johnson, K. A. (1986) Rate of ATP Synthesis by Dynein.  Biochemistry 25, 428-434. [Link]
  129. Johnson, K. A. (1986)  Kinetics of the ATP-Induced Dissociation and Re-formation of the Microtubule-Dynein Complex.  Biochemistry 25, 426-427. [Link]
  130. Omoto, C. K. and Johnson, K. A. (1986) Activation of the Dynein ATPase by  Microtubules.  Biochemistry 25, 419-426. [Link]
  131. Breen, P. J., Johnson, K. A. and Horrocks, W. DeW.  (1985)  Stopped-flow Kinetic Studies of Metal-ion Dissociation of Exchange in a Tryptophan-containing Parvalbumin. Biochemistry 24, 4997-5004. [Link]
  132. Mizrahi, V., Henrie, R. N., Marier, J. F., Johnson, K. A. and Benkovic, S. J.  (1985)  Rate-Limiting Steps in the DNA Polymerase I Reaction Pathway.  Biochemistry 24, 4010-4018. [Link]
  133. Johnson, K. A. (1985)  Pathway of the Microtubule-Dynein ATPase and the Structure of Dynein:  A Comparison with Actomyosin.  Ann. Rev. Biophys. Biophys. Chem. 14, 161-88. [Link]
  134. Johnson, K. A., Porter, M. E. and Shimizu, T. (1984)  Mechanism of Force Production for Microtubule-dependent Movements.  J. Cell Biol. 99, 132s-136s. [Link]
  135. Johnson, K. A.  (1984)  Scanning Transmission Electron Microscopy of Dynein Arms.  Ann. New York Acad. Sci. USA 438, 217-223. [Link]
  136. Johnson, K. A., Bryant, F. R. and Benkovic, S. J. (1984)  Continuous Assay for DNA Polymerization by Light Scattering.  Anal. Biochemistry 136, 192-194. [Link]
  137. Johnson, K. A., Shimizu, T. and Holzbaur, E. L. F. (1983) Kinetic Evidence for Multiple Dynein Heads: Modeling the Dissociation Reaction.  J. Biol. Chem. 258, 13847-13848. [Link]
  138. Shimizu, T. and Johnson, K. A.  (1983)  Kinetic Evidence for Multiple Dynein ATPase Sites.  J. Biol. Chem. 258, 13841-13848. [Link]
  139. Shimizu, T. and Johnson, K. A.  (1983)  Presteady State Kinetic Analysis of Vanadate-induced Inhibition of the Dynein ATPase.  J. Biol. Chem.. 258, 13833-13840. [Link]
  140. Porter ME, Johnson KA. (1983) The interaction of Tetrahymena 30S dynein with bovine brain microtubules. J. Submicrosc. Cytol. 15, 199-200. [Link]
  141. Johnson, K. A.  (1983)  The Pathway of ATP Hydrolysis by Dynein:  Kinetics of a Presteady State Phosphate Burst.  J. Biol. Chem. 258, 13825-13832. [Link]
  142. Bryant, F. R., Johnson, K. A. and Benkovic, S. J.  (1983)  Elementary Steps in the DNA Polymerase I Reaction Pathway.  Biochemistry 22, 3537-3546. [Link]
  143. Porter, M. E. and Johnson, K. A. (1983) Transient State Kinetic Analysis of the ATP-induced Dissociation of the Dynein-Microtubule Complex.  J. Biol. Chem. 258, 6582-6587. [Link]
  144. Porter, M. E. and Johnson, K. A. (1983) Characterization of the ATP-sensitive Binding of Tetrahymena 30S Dynein to Bovine Brain Microtubules.  J. Biol. Chem. 258, 6575-6581. [Link]
  145. Witman, G. B., Johnson, K. A., Pfister, K. K. and Wall, J. S.  (1983)  Fine Structure and Molecular Weight of the Outer Arm Dyneins of Chlamydomonas.  J. Submicrosc. Cyt. 15, 193-197.
  146. Johnson, K. A. and Wall J. S.  (1983)  Structural and Mass Analysis of Dynein. J. Submicrosc. Cyt. 15, 181-186.
  147. Johnson, K. A. and Wall, J. S.  (1983)  Structure and Molecular Weight of the Dynein ATPase.  J. Cell Biol. 96, 669-678. [Link]
  148. Meek, T. D., Johnson, K. A. and Villafranca, J. J. (1982)  Escherichia coli Glutamine Synthetase.  Determination of Rate-Limiting Steps by Rapid-Quench and Isotope Partitioning Experiments.  Biochemistry 21, 2158-2167. [Link]
  149. Matherly, L. H., Johnson, K. A. and Phillips, A. T.  (1982) Transient-State Kinetic Analysis of Urocanase.  Biochemistry 21, 2795-2798. [Link]
  150. Johnson, K. A. and Porter, M. E.  (1982)  Transient-State Kinetic Analysis of the Dynein ATPase.  Prog Clin Biol Res. 1, 101-106. [Link]
  151. Johnson, K. A. and Borisy, G. G.  (1979)  Thermodynamic Analysis of Microtubule Self-Assembly in vitroJ. Mol. Biol. 133, 199-216. [Link]
  152. Johnson, K. A. and Taylor, E. W.  (1978)  The Intermediate States of Subfragment-1 and Acto-Subfragment-1 ATPase-a Reevaluation of the Mechanism.  Biochemistry 17, 3432-3442.
  153. Sleep, J. A., Trybus, K. M., Johnson, K. A. and Taylor, E. W.  (1981) Kinetic Studies of Normal and Modified HMM and Subfragment-1.  J. Muscle Research and Cell Motility  2, 373-399.
  154. Johnson, K. A.  (1980)  Thermodynamics of Microtubule Assembly. In:  Proteins and Nucleoproteins:  Structure, Dynamics and Assembly.  Rockefeller University Press, pp. 78-80. [Link to Book]
  155. Murphy, D. B., Johnson, K. A. and Borisy G. G.  (1977) The Role of Tubulin-Associated Proteins in Microtubule Nucleation and Elongation.  J. Mol. Biol. 117, 33-52. [Link]
  156. Johnson, K. A. and Borisy, G. G. (1977) Kinetic Analysis of Microtubule Self-Assembly in vitroJ. Mol. Biol. 117, 1-32. [Link]
  157. Borisy, G. G., Johnson, K. A. and Marcum, J. M. (1976) Self-Assembly and Site-Initiated Assembly of Microtubules.  In:  Cell Motility, ed. by R. Goldman, T. Pollard and J. Rosenbaum, Cold Spring Harbor Laboratory, pp. 1093-1108. [Link to Book on Amazon.com]
  158. Borisy, G. G., Marcum, J. M., Olmsted, J. B., Murphy, D. B. and Johnson, K. A. (1975) Purification of Tubulin and Associated High Molecular Weight Proteins from Porcine Brain and Characterization of Microtubule Assembly in vitroAnn. New York Acad. Sci. USA 253, 107-132. [Link]
  159. Johnson, K. A. and Borisy, G. G.  (1975) The Equilibrium Assembly of Microtubules in vitro.  In: Molecules and Cell Movement, ed. by S. Inoue and R. E. Stephens, Raven Press, pp. 119-141. [Link]
  160. Olmsted, J. B., Marcum, J. M. Johnson, K. A., Allen, C. and Borisy, G. G.  (1974) Microtubule Assembly:  Some Possible Regulatory Mechanisms.  J. Supramolec. Struct. 2, 429-450. [Link]